The open access malaria box: a drug discovery catalyst for neglected diseases.
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ABSTRACT:
SUBMITTER: Spangenberg T
PROVIDER: S-EPMC3684613 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
The open access malaria box: a drug discovery catalyst for neglected diseases.
Spangenberg Thomas T Burrows Jeremy N JN Kowalczyk Paul P McDonald Simon S Wells Timothy N C TN Willis Paul P
PloS one 20130617 6
Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has yielded almost 30,000 submicromolar hits in recent years. To make this collection more accessible, a collection of 400 chemotypes has been assembled, termed the Malaria Box. Half of these compounds were selected based on their drug-like properties and the others as molecular probes. These can now be ...[more]
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