Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization.
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ABSTRACT:
SUBMITTER: Mishra A
PROVIDER: S-EPMC3684849 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
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Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization.
Mishra Aseem A Misra Anurag A Vaishnavi T Sri TS Thota Chaitanya C Gupta Madhvi M Ramakumar Suryanarayanarao S Chauhan Virander Singh VS
Chemical communications (Cambridge, England) 20130401 26
hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity. ...[more]
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