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Methyl (3S,10b'S)-5-chloro-9'-fluoro-1-methyl-2-oxo-5'-phenyl-10b'H-spiro-[indoline-3,1'-pyrazolo-[3,2-a]iso-quinoline]-2'-carboxyl-ate.

ABSTRACT: In the title compound, C27H19ClFN3O3, the pyrazole ring has a twist conformation and the six-membered ring to which it is fused has a screw-boat conformation. The mean plane of the pyrazole ring is inclined to the 2-methyl-indoline ring by 85.03?(9) and by 28.17?(8)° to the mean plane of the iso-quinoline ring system. In the crystal, mol-ecules are linked by pairs of C-H?F hydrogen bonds, forming inversion dimers. These dimers are linked via C-H?O hydrogen bonds, forming a two-dimensional network lying parallel to (10-1).

SUBMITTER: Kannan PS

PROVIDER: S-EPMC3684913 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Methyl (3S,10b'S)-5-chloro-9'-fluoro-1-methyl-2-oxo-5'-phenyl-10b'H-spiro-[indoline-3,1'-pyrazolo-[3,2-a]iso-quinoline]-2'-carboxyl-ate.

Kannan Piskala Subburaman PS Yuvaraj Panneerselvam P Reddy Boreddy Siva Rami BS Raja Rajamani R Subbiahpandi Arunachalathevar A

Acta crystallographica. Section E, Structure reports online 20130504 Pt 6

In the title compound, C27H19ClFN3O3, the pyrazole ring has a twist conformation and the six-membered ring to which it is fused has a screw-boat conformation. The mean plane of the pyrazole ring is inclined to the 2-methyl-indoline ring by 85.03 (9) and by 28.17 (8)° to the mean plane of the iso-quinoline ring system. In the crystal, mol-ecules are linked by pairs of C-H⋯F hydrogen bonds, forming inversion dimers. These dimers are linked via C-H⋯O hydrogen bonds, forming a two-dimensional networ ...[more]

PMID: 23795015

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