SNPs in CAST are associated with Parkinson disease: a confirmation study.
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ABSTRACT:
SUBMITTER: Allen AS
PROVIDER: S-EPMC3685412 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
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SNPs in CAST are associated with Parkinson disease: a confirmation study.
Allen Andrew S AS Satten Glen A GA
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20100601 4
Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant ass ...[more]
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