Peripheral blood gene expression signature differentiates children with autism from unaffected siblings.
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ABSTRACT:
SUBMITTER: Kong SW
PROVIDER: S-EPMC3686296 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Peripheral blood gene expression signature differentiates children with autism from unaffected siblings.
Kong S W SW Shimizu-Motohashi Y Y Campbell M G MG Lee I H IH Collins C D CD Brewster S J SJ Holm I A IA Rappaport L L Kohane I S IS Kunkel L M LM
Neurogenetics 20130428 2
Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental disorders with high heritability, yet a majority of genetic contribution to pathophysiology is not known. Siblings of individuals with ASD are at increased risk for ASD and autistic traits, but the genetic contribution for simplex families is estimated to be less when compared to multiplex families. To explore the genomic (dis-) similarity between proband and unaffected sibling in simplex families, we used genome-wide ...[more]
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