Dataset Information

Longitudinal Assessment of Amyloid Pathology in Transgenic ArcA? Mice Using Multi-Parametric Magnetic Resonance Imaging.

ABSTRACT: Magnetic resonance imaging (MRI) can be used to monitor pathological changes in Alzheimer's disease (AD). The objective of this longitudinal study was to assess the effects of progressive amyloid-related pathology on multiple MRI parameters in transgenic arcA? mice, a mouse model of cerebral amyloidosis. Diffusion-weighted imaging (DWI), T1-mapping and quantitative susceptibility mapping (QSM), a novel MRI based technique, were applied to monitor structural alterations and changes in tissue composition imposed by the pathology over time. Vascular function and integrity was studied by assessing blood-brain barrier integrity with dynamic contrast-enhanced MRI and cerebral microbleed (CMB) load with susceptibility weighted imaging and QSM. A linear mixed effects model was built for each MRI parameter to incorporate effects within and between groups (i.e. genotype) and to account for changes unrelated to the disease pathology. Linear mixed effects modelling revealed a strong association of all investigated MRI parameters with age. DWI and QSM in addition revealed differences between arcA? and wt mice over time. CMBs became apparent in arcA? mice with 9 month of age; and the CMB load reflected disease stage. This study demonstrates the benefits of linear mixed effects modelling of longitudinal imaging data. Moreover, the diagnostic utility of QSM and assessment of CMB load should be exploited further in studies of AD.

SUBMITTER: Klohs J

PROVIDER: S-EPMC3686820 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging.

Klohs Jan J Politano Igna Wojtyna IW Deistung Andreas A Grandjean Joanes J Drewek Anna A Dominietto Marco M Keist Ruth R Schweser Ferdinand F Reichenbach Jürgen R JR Nitsch Roger M RM Knuesel Irene I Rudin Markus M

PloS one 20130619 6

Magnetic resonance imaging (MRI) can be used to monitor pathological changes in Alzheimer's disease (AD). The objective of this longitudinal study was to assess the effects of progressive amyloid-related pathology on multiple MRI parameters in transgenic arcAβ mice, a mouse model of cerebral amyloidosis. Diffusion-weighted imaging (DWI), T1-mapping and quantitative susceptibility mapping (QSM), a novel MRI based technique, were applied to monitor structural alterations and changes in tissue comp ...[more]

PMID: 23840405

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Dataset Information

Longitudinal Assessment of Amyloid Pathology in Transgenic ArcA? Mice Using Multi-Parametric Magnetic Resonance Imaging.

Publications

Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging.

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