Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC3686853 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Yang Feng F Zhang Yongyou Y Ressler Steven J SJ Ittmann Michael M MM Ayala Gustavo E GE Dang Truong D TD Wang Fen F Rowley David R DR
Cancer research 20130410 12
The fibroblast growth factor receptor 1 (FGFR1) is ectopically expressed in prostate carcinoma cells, but its functional contributions are undefined. In this study, we report the evaluation of a tissue-specific conditional deletion mutant generated in an ARR2PBi(Pbsn)-Cre/TRAMP/fgfr1(loxP/loxP) transgenic mouse model of prostate cancer. Mice lacking fgfr1, in prostate cells developed smaller tumors that also included distinct cancer foci still expressing fgfr1 indicating focal escape from gene e ...[more]