Ontology highlight
ABSTRACT:
SUBMITTER: Pakala SB
PROVIDER: S-EPMC3686857 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cancer research 20130411 12
Overexpression of the prometastatic chromatin modifier protein metastasis tumor antigen 1 (MTA1) in human cancer contributes to tumor aggressiveness, but the role of endogenous MTA1 in cancer has not been explored. Here, we report the effects of selective genetic depletion of MTA1 in a physiologically relevant spontaneous mouse model of breast cancer pulmonary metastasis. We found that MTA1 acts as a mandatory modifier of breast-to-lung metastasis without effects on primary tumor formation. The ...[more]