Ontology highlight
ABSTRACT:
SUBMITTER: Almeida B
PROVIDER: S-EPMC3687200 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Almeida Bruno B Fernandes Sara S Abreu Isabel A IA Macedo-Ribeiro Sandra S
Frontiers in neurology 20130620
Trinucleotide repeat (TNR) expansions are present in a wide range of genes involved in several neurological disorders, being directly involved in the molecular mechanisms underlying pathogenesis through modulation of gene expression and/or the function of the RNA or protein it encodes. Structural and functional information on the role of TNR sequences in RNA and protein is crucial to understand the effect of TNR expansions in neurodegeneration. Therefore, this review intends to provide to the re ...[more]