Ontology highlight
ABSTRACT:
SUBMITTER: Thompson DA
PROVIDER: S-EPMC3687341 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
eLife 20130618
Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular regulatory programs along a time course of growth on glucose over 300 million years [corrected]. We found that modules have diverged proportionally to phylogenetic distance, with prominent changes in gene regulation accompanying changes in lifestyle and ploidy, especially in ...[more]