Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1.
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ABSTRACT:
SUBMITTER: Luo L
PROVIDER: S-EPMC3687373 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1.
Luo Ling L Uehara Hironori H Zhang Xiaohui X Das Subrata K SK Olsen Thomas T Holt Derick D Simonis Jacquelyn M JM Jackman Kyle K Singh Nirbhai N Miya Tadashi R TR Huang Wei W Ahmed Faisal F Bastos-Carvalho Ana A Le Yun Zheng YZ Mamalis Christina C Chiodo Vince A VA Hauswirth William W WW Baffi Judit J Lacal Pedro M PM Orecchia Angela A Ferrara Napoleone N Gao Guangping G Young-Hee Kim K Fu Yingbin Y Owen Leah L Albuquerque Romulo R Baehr Wolfgang W Thomas Kirk K Li Dean Y DY Chalam Kakarla V KV Chalam Kakarla V KV Shibuya Masabumi M Grisanti Salvatore S Wilson David J DJ Ambati Jayakrishna J Ambati Balamurali K BK
eLife 20130618
Optimal phototransduction requires separation of the avascular photoreceptor layer from the adjacent vascularized inner retina and choroid. Breakdown of peri-photoreceptor vascular demarcation leads to retinal angiomatous proliferation or choroidal neovascularization, two variants of vascular invasion of the photoreceptor layer in age-related macular degeneration (AMD), the leading cause of irreversible blindness in industrialized nations. Here we show that sFLT-1, an endogenous inhibitor of vas ...[more]
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