Discriminating between 5-HT?A and 5-HT?AB receptors.
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ABSTRACT:
SUBMITTER: Thompson AJ
PROVIDER: S-EPMC3687655 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Discriminating between 5-HT₃A and 5-HT₃AB receptors.
Thompson A J AJ Lummis S C R SC
British journal of pharmacology 20130601 4
The 5-HT3B subunit was first cloned in 1999, and co-expression with the 5-HT3A subunit results in heteromeric 5-HT₃AB receptors that are functionally distinct from homomeric 5-HT₃A receptors. The affinities of competitive ligands at the two receptor subtypes are usually similar, but those of non-competitive antagonists that bind in the pore often differ. A competitive ligand and allosteric modulator that distinguishes 5-HT₃A from 5-HT₃AB receptors has recently been described, and the number of n ...[more]
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