Ontology highlight
ABSTRACT:
SUBMITTER: Wolfe AL
PROVIDER: S-EPMC3687800 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Wolfe Amanda L AL Duncan Katharine K KK Parelkar Nikhil K NK Brown Douglas D Vielhauer George A GA Boger Dale L DL
Journal of medicinal chemistry 20130510 10
Two novel cyclic N-acyl O-amino phenol prodrugs are reported as new members of a unique class of reductively cleaved prodrugs of the duocarmycin family of natural products. These prodrugs were explored with the expectation that they may be cleaved selectively within hypoxic tumor environments that have intrinsically higher concentrations of reducing nucleophiles and were designed to liberate the free drug without the release of an extraneous group. In vivo evaluation of the prodrug 6 showed that ...[more]