Ontology highlight
ABSTRACT:
SUBMITTER: Feliu V
PROVIDER: S-EPMC3688528 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Feliu Virginie V Vasseur Virginie V Grover Harshita S HS Chu H Hamlet HH Brown Mark J MJ Wang Jeremy J Boyle Jon P JP Robey Ellen A EA Shastri Nilabh N Blanchard Nicolas N
PLoS pathogens 20130620 6
CD8 T cells protect the host from disease caused by intracellular pathogens, such as the Toxoplasma gondii (T. gondii) protozoan parasite. Despite the complexity of the T. gondii proteome, CD8 T cell responses are restricted to only a small number of peptide epitopes derived from a limited set of antigenic precursors. This phenomenon is known as immunodominance and is key to effective vaccine design. However, the mechanisms that determine the immunogenicity and immunodominance hierarchy of paras ...[more]