Immunoprotection of mice against Schistosomiasis mansoni using solubilized membrane antigens.

ABSTRACT:

Background

Schistosomiasis continues to be one of the most prevalent parasitic diseases in the world. Despite the existence of a highly effective antischistosome drug, the disease is spreading into new areas, and national control programs do not arrive to complete their tasks particularly in low endemic areas. The availability of a vaccine could represent an additional component to chemotherapy. Experimental vaccination studies are however necessary to identify parasite molecules that would serve as vaccine candidates. In the present work, C57BL/6 female mice were subcutaneously immunized with an n-butanol extract of the adult worm particulate membranous fraction (AWBE) and its protective effect against a S. mansoni challenge infection was evaluated.

Methodology and findings

SUBMITTER: Sulbaran G 

PROVIDER: S-EPMC3688544 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature