Dataset Information

Systematic examination of infant size and growth metrics as risk factors for overweight in young adulthood.

ABSTRACT:

Objective

To systematically examine infant size and growth, according to the 2006 WHO infant growth standards, as risk factors for overweight status in young adulthood in a historical cohort. Specifically, to assess: Whether accounting for length (weight-for-length) provides a different picture of risk than weight-for-age, intervals of rapid growth in both weight-for-age and weight-for-length metrics, and what particular target ages for infant size and intervals of rapid growth associate most strongly with overweight as a young adult.

Patients/methods

Data analysis of 422 appropriate for gestational age white singleton infants enrolled in the Fels Longitudinal Study. Odds ratios (OR) for overweight and obesity in young adulthood (age 20-29) were calculated using logistic regression models for the metrics at each target age (0, 1, 3, 6, 9, 12, 18, 24 months) comparing ?85(th) v. <85(th) percentile, as well as rapid growth (??0.67 Z-score) through target age intervals. Models accounted for both maternal and paternal BMI.

Results

Infants ?85(th) percentile of weight-for-age at each target age (except 3 months) had a greater odds of being overweight as a young adult. After accounting for length (weight-for-length) this association was limited to 12, and 18 months. Rapid weight-for-age growth was infrequently associated with overweight as a young adult. Rapid weight-for-length growth from 0 to 24 months, 1 to 6, 9, 12, 18, and 24 months and from 3 to 9, 12, 18, and 24 months was strongly associated with overweight status as a young adult.

Conclusions

The WHO weight-for-length metric associates differently with risk of being overweight as a young adult compared to weight-for-age. Intervals of rapid weight-for-length growth ranging from months (0-24), (1-12, 18, and 24) and (3-9, and 12) displayed the largest OR for being overweight as a young adult.

SUBMITTER: Odegaard AO

PROVIDER: S-EPMC3688577 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Systematic examination of infant size and growth metrics as risk factors for overweight in young adulthood.

Odegaard Andrew O AO Choh Audrey C AC Nahhas Ramzi W RW Towne Bradford B Czerwinski Stefan A SA Demerath Ellen W EW

PloS one 20130620 6

<h4>Objective</h4>To systematically examine infant size and growth, according to the 2006 WHO infant growth standards, as risk factors for overweight status in young adulthood in a historical cohort. Specifically, to assess: Whether accounting for length (weight-for-length) provides a different picture of risk than weight-for-age, intervals of rapid growth in both weight-for-age and weight-for-length metrics, and what particular target ages for infant size and intervals of rapid growth associate ...[more]

PMID: 23818973

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Dataset Information

Systematic examination of infant size and growth metrics as risk factors for overweight in young adulthood.

Objective

Patients/methods

Results

Conclusions

Publications

Systematic examination of infant size and growth metrics as risk factors for overweight in young adulthood.

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