Ontology highlight
ABSTRACT:
SUBMITTER: Jutras BL
PROVIDER: S-EPMC3688583 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Jutras Brandon L BL Chenail Alicia M AM Rowland Christi L CL Carroll Dustin D Miller M Clarke MC Bykowski Tomasz T Stevenson Brian B
PloS one 20130620 6
A site-specific DNA-binding protein was purified from Borrelia burgdorferi cytoplasmic extracts, and determined to be a member of the highly conserved SpoVG family. This is the first time a function has been attributed to any of these ubiquitous bacterial proteins. Further investigations into SpoVG orthologues indicated that the Staphylococcus aureus protein also binds DNA, but interacts preferentially with a distinct nucleic acid sequence. Site-directed mutagenesis and domain swapping between t ...[more]