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Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol.

ABSTRACT: Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.

SUBMITTER: Jeong JH

PROVIDER: S-EPMC3688670 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol.

Jeong Jae Hyun JH Schmidt John J JJ Kohman Richie E RE Zill Andrew T AT DeVolder Ross J RJ Smith Cartney E CE Lai Mei-Hsiu MH Shkumatov Artem A Jensen Tor W TW Schook Lawrence G LG Zimmerman Steven C SC Kong Hyunjoon H

Journal of the American Chemical Society 20130419 24

Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to th ...[more]

PMID: 23590123

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