Determinants of the Changes in Glycemic Control with Exercise Training in Type 2 Diabetes: A Randomized Trial.
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ABSTRACT: Aims
To assess the determinants of exercise training-induced improvements in glucose control (HbA1C) including changes in serum total adiponectin and FFA concentrations, and skeletal muscle peroxisome proliferator-activated receptor-? coactivator-1? (PGC-1?) protein content.Methods
A sub-cohort (n?=?35; 48% men; 74% Caucasian) from the HART-D study undertaking muscle biopsies before and after 9 months of aerobic (AT), resistance (RT), or combination training (ATRT).Results
Changes in HbA1C were associated with changes in adiponectin (r?=?-0.45, P?=?0.007). Participants diagnosed with type 2 diabetes for a longer duration had the largest increase in PGC-1? (r?=?0.44, P?=?0.008). Statistical modeling examining changes in HbA1C suggested that male sex (P?=?0.05), non-Caucasian ethnicity (P?=?0.02), duration of type 2 diabetes (r?=?0.40; P<0.002) and changes in FFA (r?=?0.36; P<0.004), adiponectin (r?=?-0.26; P<0.03), and PGC-1? (r?=?-0.28; P?=?0.02) explain ?65% of the variability in the changes in HbA1C.Conclusions
Decreases in HbA1C after 9 months of exercise were associated with shorter duration of diabetes, lowering of serum FFA concentrations, increasing serum adiponectin concentrations and increasing skeletal muscle PGC-1? protein expression.Trial registration
ClinicalTrials.gov NCT00458133.
SUBMITTER: Johannsen NM
PROVIDER: S-EPMC3689775 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Determinants of the Changes in Glycemic Control with Exercise Training in Type 2 Diabetes: A Randomized Trial.
Johannsen Neil M NM Sparks Lauren M LM Zhang Zhengyu Z Earnest Conrad P CP Smith Steven R SR Church Timothy S TS Ravussin Eric E
PloS one 20130621 6
<h4>Aims</h4>To assess the determinants of exercise training-induced improvements in glucose control (HbA1C) including changes in serum total adiponectin and FFA concentrations, and skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) protein content.<h4>Methods</h4>A sub-cohort (n = 35; 48% men; 74% Caucasian) from the HART-D study undertaking muscle biopsies before and after 9 months of aerobic (AT), resistance (RT), or combination training (ATRT).<h4>Results</h ...[more]
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