Ontology highlight
ABSTRACT:
SUBMITTER: Bateup HS
PROVIDER: S-EPMC3690324 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Bateup Helen S HS Johnson Caroline A CA Denefrio Cassandra L CL Saulnier Jessica L JL Kornacker Karl K Sabatini Bernardo L BL
Neuron 20130501 3
Neural circuits are regulated by activity-dependent feedback systems that tightly control network excitability and which are thought to be crucial for proper brain development. Defects in the ability to establish and maintain network homeostasis may be central to the pathogenesis of neurodevelopmental disorders. Here, we examine the function of the tuberous sclerosis complex (TSC)-mTOR signaling pathway, a common target of mutations associated with epilepsy and autism spectrum disorder, in regul ...[more]