Ontology highlight
ABSTRACT:
SUBMITTER: Wencewicz TA
PROVIDER: S-EPMC3690592 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Wencewicz Timothy A TA Miller Marvin J MJ
Journal of medicinal chemistry 20130508 10
Chemical syntheses and biological evaluation of biscatecholate-monohydroxamate mixed ligand sideromycins utilizing the carbacephalosporin β-lactam antibiotic loracarbef and the fluoroquinolone antibiotic ciprofloxacin are described. The mixed ligand β-lactam sideromycin (1b) had remarkably selective and extremely potent antibacterial activity against the Gram-negative pathogen Acinetobacter baumannii ATCC 17961 (MIC = 0.0078 μM). The antibacterial activity of the β-lactam sideromycin was inverse ...[more]