Ontology highlight
ABSTRACT:
SUBMITTER: Funahashi Y
PROVIDER: S-EPMC3690602 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Funahashi Yasuhiro Y Hernandez Sonia L SL Das Indranil I Ahn Audrey A Huang Jianzhong J Vorontchikhina Marina M Sharma Anshula A Kanamaru Emi E Borisenko Valeriya V Desilva Dinuka M DM Suzuki Akihiko A Wang Xing X Shawber Carrie J CJ Kandel Jessica J JJ Yamashiro Darrell J DJ Kitajewski Jan J
Cancer research 20080601 12
Notch signaling is required for vascular development and tumor angiogenesis. Although inhibition of the Notch ligand Delta-like 4 can restrict tumor growth and disrupt neovasculature, the effect of inhibiting Notch receptor function on angiogenesis has yet to be defined. In this study, we generated a soluble form of the Notch1 receptor (Notch1 decoy) and assessed its effect on angiogenesis in vitro and in vivo. Notch1 decoy expression reduced signaling stimulated by the binding of three distinct ...[more]