Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC3690710 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Zhang Lingdi L Li Xueni X Zhao Rui R
Protein science : a publication of the Protein Society 20130508 6
Pre-mRNA splicing is a critical event in the gene expression pathway of all eukaryotes. The splicing reaction is catalyzed by the spliceosome, a huge protein-RNA complex that contains five snRNAs and hundreds of different protein factors. Understanding the structure of this large molecular machinery is critical for understanding its function. Although the highly dynamic nature of the spliceosome, in both composition and conformation, posed daunting challenges to structural studies, there has bee ...[more]