Ontology highlight
ABSTRACT:
SUBMITTER: Van de Vosse DW
PROVIDER: S-EPMC3690833 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Van de Vosse David W DW Wan Yakun Y Lapetina Diego L DL Chen Wei-Ming WM Chiang Jung-Hsien JH Aitchison John D JD Wozniak Richard W RW
Cell 20130201 5
Embedded in the nuclear envelope, nuclear pore complexes (NPCs) not only regulate nuclear transport but also interface with transcriptionally active euchromatin, largely silenced heterochromatin, as well as the boundaries between these regions. It is unclear what functional role NPCs play in establishing or maintaining these distinct chromatin domains. We report that the yeast NPC protein Nup170p interacts with regions of the genome that contain ribosomal protein and subtelomeric genes, where it ...[more]