Ontology highlight
ABSTRACT:
SUBMITTER: Jojic V
PROVIDER: S-EPMC3690947 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Nature immunology 20130428 6
The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the Immunological Genome Project gene-expression profiles across mouse immune lineages allowed us to systematically analyze these circuits. To analyze this data set we developed Ontogenet, an algorithm for reconstructing lineage-specific regulation from gene-expression profiles across ...[more]