Ontology highlight
ABSTRACT:
SUBMITTER: Lin CC
PROVIDER: S-EPMC3691148 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lin Chen-Ching CC Lee Chia-Hsien CH Fuh Chiou-Shann CS Juan Hsueh-Fen HF Huang Hsuan-Cheng HC
PloS one 20130624 6
Many biological networks are signed molecular networks which consist of positive and negative links. To reveal the distinct features between links with different signs, we proposed signed link-clustering coefficients that assess the similarity of inter-action profiles between linked molecules. We found that positive links tended to cluster together, while negative links usually behaved like bridges between positive clusters. Positive links with higher adhesiveness tended to share protein domains ...[more]