Dataset Information

Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial.

ABSTRACT:

Background

Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.

Methods

We randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically stratified, randomised controlled trial. Supplementation improved but did not optimise vitamin D status. Researchers blind to allocation assessed offspring at 3 years. Primary outcome was any history of wheeze assessed by validated questionnaire. Secondary outcomes included atopy, respiratory infection, impulse oscillometry and exhaled nitric oxide. Primary analyses used logistic and linear regression.

Results

We evaluated 158 of 180 (88%) offspring at age 3 years for the primary outcome. Atopy was assessed by skin test for 95 children (53%), serum IgE for 86 (48%), exhaled nitric oxide for 62 (34%) and impulse oscillometry of acceptable quality for 51 (28%). We found no difference between supplemented and control groups in risk of wheeze [no vitamin D: 14/50 (28%); any vitamin D: 26/108 (24%) (risk ratio 0.86; 95% confidence interval 0.49, 1.50; P?=?0.69)]. There was no significant difference in atopy, eczema risk, lung function or exhaled nitric oxide between supplemented groups and controls.

Conclusion

Prenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level, was not associated with decreased wheezing in offspring at age three years.

Trial registration

Controlled-Trials.com ISRCTN68645785.

SUBMITTER: Goldring ST

PROVIDER: S-EPMC3691177 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial.

Goldring Stephen T ST Griffiths Chris J CJ Martineau Adrian R AR Robinson Stephen S Yu Christina C Poulton Sheree S Kirkby Jane C JC Stocks Janet J Hooper Richard R Shaheen Seif O SO Warner John O JO Boyle Robert J RJ

PloS one 20130624 6

<h4>Background</h4>Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.<h4>Methods</h4>We randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically stratified, randomised controlled trial. Supplementation improved bu ...[more]

PMID: 23826104

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Dataset Information

Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial.

Background

Methods

Results

Conclusion

Trial registration

Publications

Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial.

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