Dataset Information

Epidemiological analysis of HTLV-1 and HTLV-2 infection among different population in Central China.

ABSTRACT: BACKGROUND: HTLV-1 and HTLV-2 are retroviruses linked etiologically to various human diseases, and both of them can be transmitted by vertical route, sexual intercourse, blood transfusion and intravenous drug use. Recently, some HTLV-infected cases have been reported and this virus is mainly present in the Southeast coastal areas in China, but has not been studied for the people in Central China. OBJECTIVES: To know the epidemiologic patterns among different population samples in Central China and further identify risk factor for HTLV-1 and HTLV-2 infection. METHODS: From January 2008 to December 2011, 5480 blood samples were screened for HTLV-1/2 antibodies by using enzyme immunoassay, followed by Western Blot. RESULTS: The prevalence of HTLV-1 and HTLV-2 was found with infection rates 0.13% and 0.05% among all population samples for HTLV-1 and HTLV-2, respectively. The highest percentages of infection, 0.39% and 0.20%, were found in the high risk group, while only 0.06% and 0.03% in the blood donor group. There was only one case of HTLV-1 infection (0.11%) among patients with malignant hematological diseases. Of seven HTLV-1 positive cases, six were co-infected with HBV, two with HCV and one with HIV. Among three HTLV-2 positive individuals all were co-infected with HBV, one with HCV. CONCLUSIONS: HTLV-1 and HTLV-2 have been detected in the Central China at low prevalence, with the higher infection rate among high risk group. It was also found that co-infection of HTLV-1/2 with HIV and HBV occurred, presumably due to their similar transmission routes. HTLV-1/2 antibody screen among certain population would be important to prevent the spread of the viruses.

SUBMITTER: Ma Y

PROVIDER: S-EPMC3691312 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Epidemiological analysis of HTLV-1 and HTLV-2 infection among different population in Central China.

Ma Yunyun Y Zheng Shangen S Wang Na N Duan Yu Y Sun Xinyu X Jin Jing J Zang Wenqiao W Li Min M Wang Yuanyuan Y Zhao Guoqiang G

PloS one 20130624 6

<h4>Background</h4>HTLV-1 and HTLV-2 are retroviruses linked etiologically to various human diseases, and both of them can be transmitted by vertical route, sexual intercourse, blood transfusion and intravenous drug use. Recently, some HTLV-infected cases have been reported and this virus is mainly present in the Southeast coastal areas in China, but has not been studied for the people in Central China.<h4>Objectives</h4>To know the epidemiologic patterns among different population samples in Ce ...[more]

PMID: 23826136

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Dataset Information

Epidemiological analysis of HTLV-1 and HTLV-2 infection among different population in Central China.

Publications

Epidemiological analysis of HTLV-1 and HTLV-2 infection among different population in Central China.

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