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Hedgehog and Gli signaling in embryonic mammary gland development.

ABSTRACT: The first mouse mutation associated with a heritable defect in embryonic mammary gland development was Extratoes. It represents a functional null-mutation of the gene encoding Gli3, which is best known as a transcription factor mediating canonical Hedgehog (Hh) signaling. Here we review the roles of Hh and Gli proteins in murine embryonic mammary development. We propose that an off-state for Hh signaling, mediated by Gli3-repressor, is determinant for induction of a mammary instead of hair follicle fate in the trunk surface ectoderm.

SUBMITTER: Lee MY

PROVIDER: S-EPMC3691482 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Hedgehog and Gli signaling in embryonic mammary gland development.

Lee May Yin MY Sun Li L Veltmaat Jacqueline M JM

Journal of mammary gland biology and neoplasia 20130516 2

The first mouse mutation associated with a heritable defect in embryonic mammary gland development was Extratoes. It represents a functional null-mutation of the gene encoding Gli3, which is best known as a transcription factor mediating canonical Hedgehog (Hh) signaling. Here we review the roles of Hh and Gli proteins in murine embryonic mammary development. We propose that an off-state for Hh signaling, mediated by Gli3-repressor, is determinant for induction of a mammary instead of hair folli ...[more]

PMID: 23677624

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