Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC3691559 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Li Wei W Puertollano Rosa R Bonifacino Juan S JS Overbeek Paul A PA Everett Eric T ET
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 20100302 6
Development of the secondary palate in mammals is a complex process that can be easily perturbed, leading to the common and distressing birth defect cleft palate. Animal models are particularly useful tools for dissecting underlying genetic components of cleft palate. We describe a new cleft palate model resulting from a transgene insertion mutation. Transgene insertional mutagenesis disrupts the genomic organization and expression of the Ap2β1 gene located on chromosome 11. This gene encodes th ...[more]