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Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia.

ABSTRACT: Women with human papillomavirus (HPV) infections are at risk for developing squamous intraepithelial lesions (SIL) of the cervix; however, other factors are required for infections to progress to SIL. We hypothesize that consumption of fruits and vegetables high in antioxidant nutrients may prevent, in part, the development of HPV-associated SIL.This study is a nested case-control study of 265 HPV-positive women (93 SIL cases and 172 cytologically normal controls) in the Ludwig-McGill Cohort Study, São Paulo, Brazil. Diet was assessed by a self-administered food frequency questionnaire. The association between food and nutrient intake of antioxidants and incident SIL was determined by logistic regression and multinomial regression when comparing LSIL and HSILs.Higher reported consumption of papaya was inversely associated with risk of SIL (p trend=0.01) and strongest for >or=1 time/week (adjusted odds ratios (AORs)=0.19; 95%CI, 0.08-0.49). Risk of SIL was reduced among women reporting consumption of oranges >or=1 time/week (AOR=0.32; 95%CI, 0.12-0.87; p-trend=0.02). Nutrient intakes of ss-cryptoxanthin and alpha-carotene were marginally protective against SIL.Frequent consumption of fruits high in antioxidant nutrients appears to be associated with reduced risk of incident SIL among Brazilian women.

SUBMITTER: Siegel EM

PROVIDER: S-EPMC3691953 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia.

Siegel Erin M EM Salemi Jason L JL Villa Luisa L LL Ferenczy Alex A Franco Eduardo L EL Giuliano Anna R AR

Gynecologic oncology 20100618 3

<h4>Objective</h4>Women with human papillomavirus (HPV) infections are at risk for developing squamous intraepithelial lesions (SIL) of the cervix; however, other factors are required for infections to progress to SIL. We hypothesize that consumption of fruits and vegetables high in antioxidant nutrients may prevent, in part, the development of HPV-associated SIL.<h4>Methods</h4>This study is a nested case-control study of 265 HPV-positive women (93 SIL cases and 172 cytologically normal control ...[more]

PMID: 20691333

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Project description:Background: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China.Methods: Data on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. Study randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutrient intake quartile relative to that in the highest quartile.Results: The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR?=?1.55, 95% CI 1.03-2.33). Similar results were also observed for vitamin B6 (OR?=?1.63, 95% CI 1.08-2.46), vitamin C (OR?=?1.59, 95% CI 1.05-2.42), niacin (OR?=?1.65, 95% CI 1.08-2.51), and vitamin K (second versus fourth quartile: OR?=?1.60, 95% CI 1.05-2.44).Conclusions: Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer. Trial registration The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) ( https://www.chictr.org.cn ).

Dataset Information

Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia.

Publications

Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia.

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