Ontology highlight
ABSTRACT:
SUBMITTER: Tranos P
PROVIDER: S-EPMC3692343 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Tranos Paris P Vacalis Athanasios A Asteriadis Solon S Koukoula Stavrenia S Vachtsevanos Athanasios A Perganta Georgia G Georgalas Ilias I
Drug design, development and therapy 20130617
Age-related macular degeneration (AMD) is the main cause of visual impairment and blindness in people aged over 65 years in developed countries. Vascular endothelial growth factor (VEGF) is a positive regulator of angiogenesis and its proven role in the pathological neovascularization in wet AMD has provided evidence for the use of anti-VEGF agents as potential therapies. In this study, we review the literature for the possible causes of failure after treatment with anti-VEGF agents and attempt ...[more]