Association of vitamin D receptor BsmI gene polymorphism with risk of tuberculosis: a meta-analysis of 15 studies.

ABSTRACT:

Background

Genetic variations in vitamin D receptor (VDR) may contribute to tuberculosis (TB) risk. Many studies have investigated the association between VDR BsmI gene polymorphism and TB risk, but yielded inconclusive results.

Methodology/principal findings

We performed a comprehensive meta-analysis of 15 publications with a total of 2309 cases and 3568 controls. We assessed the strength of the association between VDR BsmI gene polymorphism and TB risk and performed sub-group analyses by ethnicity, sample size and Hardy-Weinberg equilibrium (HWE). We found a statistically significant correlation between VDR BsmI gene polymorphism and decreased TB risk in four comparison models: allele model (b vs. B: OR?=?0.78, 95% CI?=?0.67, 0.89; Pheterogeneity?=?0.004), homozygote model (bb vs. BB: OR?=?0.61, 95% CI?=?0.43, 0.87; Pheterogeneity?=?0.001), recessive model (bb vs. Bb+BB: OR?=?0.70, 95% CI?=?0.56, 0.88; Pheterogeneity?=?0.005) and dominant model (bb+Bb vs. BB: OR?=?0.77, 95% CI?=?0.61, 0.97; Pheterogeneity?=?0.010), especially in studies based on Asian population. Sub-group analyses also revealed that there was a statistically decreased TB risk in "small" studies (<500 participants) and studies with PHWE>0.5. Meta-regression and stratification analysis both showed that the ethnicity and sample size contributed to heterogeneity.

Conclusions

This meta-analysis suggests that VDR BsmI gene polymorphism is associated with a significant decreased TB risk, especially in Asian population.

SUBMITTER: Wu YJ 

PROVIDER: S-EPMC3692555 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature