Ontology highlight
ABSTRACT:
SUBMITTER: Feenstra B
PROVIDER: S-EPMC3693399 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Feenstra Bjarke B Geller Frank F Krogh Camilla C Hollegaard Mads V MV Gørtz Sanne S Boyd Heather A HA Murray Jeffrey C JC Hougaard David M DM Melbye Mads M
Nature genetics 20120205 3
Infantile hypertrophic pyloric stenosis (IHPS) is a severe condition characterized by hypertrophy of the pyloric sphincter muscle. We conducted a genome-wide association study (GWAS) on 1,001 surgery-confirmed cases and 2,401 controls from Denmark. The six most strongly associated loci were tested in a replication set of 796 cases and 876 controls. Three SNPs reached genome-wide significance. One of these SNPs, rs11712066 (odds ratio (OR) = 1.61; P = 1.5 × 10(-17)) at 3p25.1, is located 150 kb u ...[more]