Ontology highlight
ABSTRACT:
SUBMITTER: Spano S
PROVIDER: S-EPMC3693731 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Spanò Stefania S Galán Jorge E JE
Science (New York, N.Y.) 20121101 6109
Unlike other Salmonellae, the intracellular bacterial human pathogen Salmonella Typhi exhibits strict host specificity. The molecular bases for this restriction are unknown. Here we found that the expression of a single type III secretion system effector protein from broad-host Salmonella Typhimurium allowed Salmonella Typhi to survive and replicate within macrophages and tissues from mice, a nonpermissive host. This effector proteolytically targeted Rab32, which controls traffic to lysosome-rel ...[more]