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Molecular characterization of human adenovirus infection in Thailand, 2009-2012.


ABSTRACT: BACKGROUND: Human adenovirus (HAdV) can cause a wide spectrum of human diseases worldwide. METHODS: Using PCR and sequence analysis, we investigated HAdV infection prevalence in the Thai population for four years from January 2009 to December 2012. We collected Nasopharyngeal swab/aspirate (NP) specimens from patients in Bangkok, Khon Kaen, and Nakhon Si Thammarat province and fecal specimens only from Bangkok and Khon Kaen province. RESULTS: We observed HAdV infection in 1.04% (82/7,921) of NP samples and in 5.84% (76/1,301) of fecal specimens. HAdV-B3 (32%) and HAdV-C1 (31%) were the genotypes most commonly associated with NP specimens followed by HAdV-C2 (13%) and HAdV-C5 (12%). In fecal specimens, we found that 25% harbored HAdV-F41 followed by HAdV-C1 (18%), HAdV-C2 (16%), and HAdV-B3 (13%). Out of all population subsets, children below the age of 3 years were the most likely to be HAdV positive (63.29%). In addition, HAdV infection occurred throughout the year without a seasonal distribution pattern, although HAdV infection of NP samples peaked from January-April while HAdV infection peaked from January to March and then again from May to July in fecal samples. CONCLUSIONS: This study has for the first time reported the HAdV infection rate in Thai NP and fecal specimens from 2009-2012. We observed that HAdV-B3 and HAdV-C1 were commonly found in NP specimens, and that HAdV-F41 was the most prevalence in fecal specimens in Thailand during the study period.

SUBMITTER: Sriwanna P 

PROVIDER: S-EPMC3693972 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Molecular characterization of human adenovirus infection in Thailand, 2009-2012.

Sriwanna Punsinee P   Chieochansin Thaweesak T   Vuthitanachot Chanpim C   Vuthitanachot Viboonsuk V   Theamboonlers Apiradee A   Poovorawan Yong Y  

Virology journal 20130613


<h4>Background</h4>Human adenovirus (HAdV) can cause a wide spectrum of human diseases worldwide.<h4>Methods</h4>Using PCR and sequence analysis, we investigated HAdV infection prevalence in the Thai population for four years from January 2009 to December 2012. We collected Nasopharyngeal swab/aspirate (NP) specimens from patients in Bangkok, Khon Kaen, and Nakhon Si Thammarat province and fecal specimens only from Bangkok and Khon Kaen province.<h4>Results</h4>We observed HAdV infection in 1.04  ...[more]

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