Ontology highlight
ABSTRACT:
SUBMITTER: Cybulski C
PROVIDER: S-EPMC3694242 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cybulski C C Wokołorczyk D D Kluźniak W W Kashyap A A Gołąb A A Słojewski M M Sikorski A A Puszyński M M Soczawa M M Borkowski T T Borkowski A A Antczak A A Przybyła J J Sosnowski M M Małkiewicz B B Zdrojowy R R Domagała P P Piotrowski K K Menkiszak J J Krzystolik K K Gronwald J J Jakubowska A A Górski B B Dębniak T T Masojć B B Huzarski T T Muir K R KR Lophatananon A A Lubiński J J Narod S A SA
British journal of cancer 20130530 12
<h4>Background</h4>To evaluate whether genotyping for 18 prostate cancer founder variants is helpful in identifying high-risk individuals and for determining optimal screening regimens.<h4>Methods</h4>A serum PSA level was measured and a digital rectal examination (DRE) was performed on 2907 unaffected men aged 40-90. Three hundred and twenty-three men with an elevated PSA (≥4 ng ml⁻¹) or an abnormal DRE underwent a prostate biopsy. All men were genotyped for three founder alleles in BRCA1 (5382 ...[more]