Ontology highlight
ABSTRACT:
SUBMITTER: Levy HC
PROVIDER: S-EPMC3694330 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Levy Hazel C HC Bowman Valorie D VD Govindasamy Lakshmanan L McKenna Robert R Nash Kevin K Warrington Kenneth K Chen Weijun W Muzyczka Nicholas N Yan Xiaodong X Baker Timothy S TS Agbandje-McKenna Mavis M
Journal of structural biology 20081213 3
Adeno-associated virus serotype 2 (AAV2) uses heparan sulfate proteoglycan as a cell surface-attachment receptor. In this study the structures of AAV2 alone and complexed with heparin were determined to approximately 18A resolution using cryo-electron microscopy and three-dimensional image reconstruction. A difference map showed positive density, modeled as heparin, close to the icosahedral twofold axes and between the protrusions that surround the threefold axes of the capsid. Regions of the mo ...[more]