Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3694421 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Zhang Yan Y Heidrich Nadja N Ampattu Biju Joseph BJ Gunderson Carl W CW Seifert H Steven HS Schoen Christoph C Vogel Jörg J Sontheimer Erik J EJ
Molecular cell 20130501 4
CRISPR interference confers adaptive, sequence-based immunity against viruses and plasmids and is specified by CRISPR RNAs (crRNAs) that are transcribed and processed from spacer-repeat units. Pre-crRNA processing is essential for CRISPR interference in all systems studied thus far. Here, our studies of crRNA biogenesis and CRISPR interference in naturally competent Neisseria spp. reveal a unique crRNA maturation pathway in which crRNAs are transcribed from promoters that are embedded within eac ...[more]