Ontology highlight
ABSTRACT:
SUBMITTER: Erkeland SJ
PROVIDER: S-EPMC369447 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Erkeland Stefan J SJ Valkhof Marijke M Heijmans-Antonissen Claudia C van Hoven-Beijen Antoinette A Delwel Ruud R Hermans Mirjam H A MH Touw Ivo P IP
Journal of virology 20040201 4
Acute myeloid leukemia (AML) is a heterogeneous group of diseases in which chromosomal aberrations, small insertions or deletions, or point mutations in certain genes have profound consequences for prognosis. However, the majority of AML patients present without currently known genetic defects. Retroviral insertion mutagenesis in mice has become a powerful tool for identifying new disease genes involved in the pathogenesis of leukemia and lymphoma. Here we have used the Graffi-1.4 strain of muri ...[more]