Potential role of meiosis proteins in melanoma chromosomal instability.
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ABSTRACT:
SUBMITTER: Lindsey SF
PROVIDER: S-EPMC3694528 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Potential role of meiosis proteins in melanoma chromosomal instability.
Lindsey Scott F SF Byrnes Diana M DM Eller Mark S MS Rosa Ashley M AM Dabas Nitika N Escandon Julia J Grichnik James M JM
Journal of skin cancer 20130612
Melanomas demonstrate chromosomal instability (CIN). In fact, CIN can be used to differentiate melanoma from benign nevi. The exact molecular mechanisms that drive CIN in melanoma have yet to be fully elucidated. Cancer/testis antigens are a unique group of germ cell proteins that are found to be primarily expressed in melanoma as compared to benign nevi. The abnormal expression of these germ cell proteins, normally expected only in the testis and ovaries, in somatic cells may lead to interferen ...[more]
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