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Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer.

ABSTRACT: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. Our objective was to evaluate the risk of pancreatic cancer associated with nutrients found in fruits and vegetables and nutrient supplementation using a clinic-based case-control design.Our study included 384 rapidly ascertained cases and 983 controls frequency-matched on age at time of recruitment (in 5-year increments), race, sex, and region of residence. All subjects provided demographic information and completed a 144-item food frequency questionnaire in which they reported no change to their diet within 5 years prior to entering the study. Logistic regression was used to calculate odds ratios and 95 % confidence intervals, adjusted for age, sex, smoking, body mass index, energy intake, and alcohol consumption.Results show a significant (trend p value < 0.05) inverse association between pancreatic cancer and nutrient/supplement groupings in a dose-dependent manner including magnesium, potassium, selenium, alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein and zeaxanthin, niacin, total alpha-tocopherol, total vitamin A activity, vitamin B6, and vitamin C. Adjusting for diabetes or total sugar intake did not result in significant changes.We conclude that most nutrients obtained through consumption of fruits and vegetables may reduce the risk of developing pancreatic cancer.

SUBMITTER: Jansen RJ

PROVIDER: S-EPMC3694591 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer.

Jansen Rick J RJ Robinson Dennis P DP Stolzenberg-Solomon Rachael Z RZ Bamlet William R WR de Andrade Mariza M Oberg Ann L AL Rabe Kari G KG Anderson Kristin E KE Olson Janet E JE Sinha Rashmi R Petersen Gloria M GM

Journal of gastrointestinal cancer 20130601 2

<h4>Purpose</h4>Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. Our objective was to evaluate the risk of pancreatic cancer associated with nutrients found in fruits and vegetables and nutrient supplementation using a clinic-based case-control design.<h4>Methods</h4>Our study included 384 rapidly ascertained cases and 983 controls frequency-matched on age at time of recruitment (in 5-year increments), race, sex, and region of residence. All ...[more]

PMID: 23620017

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Project description:ObjectiveTo evaluate the association between fruit and vegetable intake during adolescence and early adulthood and risk of breast cancer.DesignProspective cohort study.SettingHealth professionals in the United States.Participants90 476 premenopausal women aged 27-44 from the Nurses' Health Study II who completed a questionnaire on diet in 1991 as well as 44 223 of those women who completed a questionnaire about their diet during adolescence in 1998.Main outcome measureIncident cases of invasive breast cancer, identified through self report and confirmed by pathology report.ResultsThere were 3235 cases of invasive breast cancer during follow-up to 2013. Of these, 1347 cases were among women who completed a questionnaire about their diet during adolescence (ages 13-18). Total fruit consumption during adolescence was associated with a lower risk of breast cancer. The hazard ratio was 0.75 (95% confidence interval 0.62 to 0.90; P=0.01 for trend) for the highest (median intake 2.9 servings/day) versus the lowest (median intake 0.5 serving/day) fifth of intake. The association for fruit intake during adolescence was independent of adult fruit intake. There was no association between risk and total fruit intake in early adulthood and total vegetable intake in either adolescence or early adulthood. Higher early adulthood intake of fruits and vegetables rich in α carotene was associated with lower risk of premenopausal breast cancer. The hazard ratio was 0.82 (0.70 to 0.96) for the highest fifth (median intake 0.5 serving/day) versus the lowest fifth (median intake 0.03 serving/day) intake. The association with adolescent fruit intake was stronger for both estrogen and progesterone receptor negative cancers than estrogen and progesterone receptor positive cancers (P=0.02 for heterogeneity). For individual fruits and vegetables, greater consumption of apple, banana, and grapes during adolescence and oranges and kale during early adulthood was significantly associated with a reduced risk of breast cancer. Fruit juice intake in adolescence or early adulthood was not associated with risk.ConclusionThere is an association between higher fruit intake and lower risk of breast cancer. Food choices during adolescence might be particularly important.

Dataset Information

Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer.

Publications

Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer.

Similar Datasets

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