Ontology highlight
ABSTRACT:
SUBMITTER: Scheffler K
PROVIDER: S-EPMC3694593 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Scheffler Katja K Krohn Markus M Dunkelmann Tina T Stenzel Jan J Miroux Bruno B Ibrahim Saleh S von Bohlen Und Halbach Oliver O von Bohlen Und Halbach Oliver O Heinze Hans-Jochen HJ Walker Lary C LC Gsponer Jörg A JA Pahnke Jens J
Acta neuropathologica 20120418 2
Several lines of evidence link mutations and deletions in mitochondrial DNA (mtDNA) and its maternal inheritance to neurodegenerative diseases in the elderly. Age-related mutations of mtDNA modulate the tricarboxylic cycle enzyme activity, mitochondrial oxidative phosphorylation capacity and oxidative stress response. To investigate the functional relevance of specific mtDNA polymorphisms of inbred mouse strains in the proteostasis regulation of the brain, we established novel mitochondrial cong ...[more]