Ontology highlight
ABSTRACT:
SUBMITTER: Snyder DS
PROVIDER: S-EPMC3694630 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20130501 5
We previously reported benzopyrimido-pyrrolo-oxazinedione (BPO) inhibitors of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel and showed their efficacy in a model of polycystic kidney disease. Here, we separated the enantiomers of lead compound BPO-27, (<b>1</b>), which contains a single chiral center, and determined their absolute configuration, activity and metabolic stability. Following separation by chiral supercritical fluid chromatography, the <i>R</i> enant ...[more]