Ontology highlight
ABSTRACT:
SUBMITTER: Crabbe L
PROVIDER: S-EPMC3694759 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Crabbe Laure L Cesare Anthony J AJ Kasuboski James M JM Fitzpatrick James A J JA Karlseder Jan J
Cell reports 20121220 6
Telomeres are essential for nuclear organization in yeast and during meiosis in mice. Exploring telomere dynamics in living human cells by advanced time-lapse confocal microscopy allowed us to evaluate the spatial distribution of telomeres within the nuclear volume. We discovered an unambiguous enrichment of telomeres at the nuclear periphery during postmitotic nuclear assembly, whereas telomeres were localized more internally during the rest of the cell cycle. Telomere enrichment at the nuclear ...[more]