Ontology highlight
ABSTRACT:
SUBMITTER: Hansen SJ
PROVIDER: S-EPMC3694803 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Virology 20110221 2
Orthopoxviruses encode multiple proteins that modulate host immune responses. We determined whether cowpox virus (CPXV), a representative orthopoxvirus, modulated innate and acquired immune functions of human primary myeloid DCs and plasmacytoid DCs and monocyte-derived DCs (MDDCs). A CPXV infection of DCs at a multiplicity of infection of 10 was nonproductive, altered cellular morphology, and failed to reduce cell viability. A CPXV infection of DCs did not stimulate cytokine or chemokine secret ...[more]