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Fetal DNA Methylation Associates with Early Spontaneous Preterm Birth and Gestational Age.


ABSTRACT: Spontaneous preterm birth (PTB, <37 weeks gestation) is a major public health concern, and children born preterm have a higher risk of morbidity and mortality throughout their lives. Recent studies suggest that fetal DNA methylation of several genes varies across a range of gestational ages (GA), but it is not yet clear if fetal epigenetic changes associate with PTB. The objective of this study is to interrogate methylation patterns across the genome in fetal leukocyte DNA from African Americans with early PTB (24(1/7)-34(0/7) weeks; N?=?22) or term births (39(0/7)-40(6/7)weeks; N?=?28) and to evaluate the association of each CpG site with PTB and GA. DNA methylation was assessed across the genome with the HumanMethylation450 BeadChip. For each individual sample and CpG site, the proportion of DNA methylation was estimated. The associations between methylation and PTB or GA were evaluated by fitting a separate linear model for each CpG site, adjusting for relevant covariates. Overall, 29 CpG sites associated with PTB (FDR<.05; 5.7×10(-10)

SUBMITTER: Parets SE 

PROVIDER: S-EPMC3694903 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Fetal DNA Methylation Associates with Early Spontaneous Preterm Birth and Gestational Age.

Parets Sasha E SE   Conneely Karen N KN   Kilaru Varun V   Fortunato Stephen J SJ   Syed Tariq Ali TA   Saade George G   Smith Alicia K AK   Menon Ramkumar R  

PloS one 20130627 6


Spontaneous preterm birth (PTB, <37 weeks gestation) is a major public health concern, and children born preterm have a higher risk of morbidity and mortality throughout their lives. Recent studies suggest that fetal DNA methylation of several genes varies across a range of gestational ages (GA), but it is not yet clear if fetal epigenetic changes associate with PTB. The objective of this study is to interrogate methylation patterns across the genome in fetal leukocyte DNA from African Americans  ...[more]

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