Ontology highlight
ABSTRACT:
SUBMITTER: Tabe Y
PROVIDER: S-EPMC3695026 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Tabe Yoko Y Shi Yue Xi YX Zeng Zhihong Z Jin Linhua L Shikami Masato M Hatanaka Yasuhito Y Miida Takashi T Hsu Frank J FJ Andreeff Michael M Konopleva Marina M
PloS one 20130627 6
Hypoxia and interactions with bone marrow (BM) stromal cells have emerged as essential components of the leukemic BM microenvironment in promoting leukemia cell survival and chemoresistance. High levels of transforming growth factor beta 1 (TGFβ1) produced by BM stromal cells in the BM niche regulate cell proliferation, survival, and apoptosis, depending on the cellular context. Exogenous TGFβ1 induced accumulation of acute myeloid leukemia (AML) cells in a quiescent G0 state, which was further ...[more]