Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves JT
PROVIDER: S-EPMC3695061 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Gonçalves J Tiago JT Anstey James E JE Golshani Peyman P Portera-Cailliau Carlos C
Nature neuroscience 20130602 7
Subtle alterations in how cortical network dynamics are modulated by different behavioral states could disrupt normal brain function and underlie symptoms of neuropsychiatric disorders, including Fragile X syndrome (FXS). Using two-photon calcium imaging and electrophysiology, we recorded spontaneous neuronal ensemble activity in mouse somatosensory cortex. Unanesthetized Fmr1(-/-) mice exhibited abnormally high synchrony of neocortical network activity, especially during the first two postnatal ...[more]