Ontology highlight
ABSTRACT:
SUBMITTER: Leen AM
PROVIDER: S-EPMC3695359 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Leen Ann M AM Bollard Catherine M CM Mendizabal Adam M AM Shpall Elizabeth J EJ Szabolcs Paul P Antin Joseph H JH Kapoor Neena N Pai Sung-Yun SY Rowley Scott D SD Kebriaei Partow P Dey Bimalangshu R BR Grilley Bambi J BJ Gee Adrian P AP Brenner Malcolm K MK Rooney Cliona M CM Heslop Helen E HE
Blood 20130422 26
Virus-specific T cell (VST) lines could provide useful antiviral prophylaxis and treatment of immune-deficient patients if it were possible to avoid the necessity of generating a separate line for each patient, often on an emergency basis. We prepared a bank of 32 virus-specific lines from individuals with common HLA polymorphisms who were immune to Epstein-Barr virus (EBV), cytomegalovirus, or adenovirus. A total of 18 lines were administered to 50 patients with severe, refractory illness becau ...[more]